MeSsy with Christina Applegate & Jamie-Lynn Sigler

On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.

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Recent Reviews
  • Ro7813
    MeSsy
    Love to relate with your journeys and appreciate your suggestions
  • CIDP warrior
    Not MS
    I don't have MS, I have chronic inflammatory demyelinating polyneuropathy. A sort of sister to MS, they share many of the same symptoms. It's very rare so I know no one with CIDP other than myself. I find a lot of emotional and mental clarity listening to this show and appreciate their willingness to be so open about Everything. .
  • Madam-Mim
    Love this show
    Love this show. Jamie is so inspiring and thoughtful.
  • GavConMom
    Help for others
    I just wanted to give a resource for those who write in and don’t have people to support them in the illness and pain. U.S Pain Foundation has peer led support groups daily and almost 70 a month. These groups provide compassion, empathy and care for those who just “get it” when no one else does unless you’re in it!
  • Raven_Gee
    Great Podcast
    I love this podcast! Jamie Lynn and Christina are so open and real. The episode with Mel Robbins was phenomenal. Thank you for sharing your experiences so authentically. Your conversations open the door for others to embrace their messiness and find healing.
  • #Kuschi Kopi's Revenge
    A Lifeline for Anyone Facing Chronic Challenges
    I don’t have multiple sclerosis, but I do have Stage IV cancer, I was incredibly healthy and relatively young, and will now be on chemo for the rest of my life. I cannot thank you enough for creating a podcast that helps so many people, including those like me who are navigating their own chronic conditions. Your insights and perspectives are so impactful that I often find myself pausing the episode just to fully absorb what you’ve shared. Your show is a lifeline of hope, understanding, and practical advice, and I’m endlessly grateful for the work you do. Thank you for making such a difference. Also, thank you so much for gifting us with your show, Dead to Me. Every episode is fantastic, but when I’m really upset, I often rewatch one of the first six episodes. You’ve beautifully incorporated authentic acting with real feelings and emotions, which is truly remarkable. You are both brilliant and inspiring, and I’m absolutely starstruck.
  • kbhollow
    Fun and more fun!
    A great listen and I have been enjoying the guest! I would love to hear from Selma Blair! She was the first voice of MS for many!
  • jbosborn281
    Motility issues
    are real. I had a total colectomy - no colon left and issues disappeared:) just fyi
  • nanny 21
    2nd tattoo
    I think you both should get the double D dragon tattoo that Jamie suggested
  • Deannamed
    Still not sure
    I was diagnosed with optic neuritis and then MS exactly 9 years ago. But 2 years ago after I moved my new Dr wasn’t sold on me actually having MS. He said I 90% fit the mold but 10% has him doubting it. I remain on the same drugs. luckily I haven’t had any symptoms in a while . so for now I’m still in the club I guess. What’s scary is differentiating MS symptoms with menopause!!!! Some of it all sounds the same according to all the new tv ads these days for menopause relief!!! How do I know what’s causing the brain fog or tiredness now? Grrr
  • BeckySueIndy
    Thank you!
    I’m so thankful I stumbled upon your podcast! I’ve learned more about MS and living skills from your podcast show than my horrible neurologist that I’ve recently fired…long story! Anyway, thank you for sharing your Hope, strength and experience and validating that I’m not crazy!
  • Anita254
    Raw conversations
    Insightful, honest and inspiring - I appreciate the views of these ladies. It isn’t a candy coated version of MS. At times I laugh and sometimes I cry. If you truly want to hear how vulnerable one can be following a diagnosis of MS- These ladies have lead fantastic careers as actresses and were extremely independent until MS consumed their bodies. No, they don’t take this lying down…. They educate, reach out to each other and help others get through a moment when life gets Messy. Love you both and want you to know each of you are a blessing. Hope you find strength and peace when things get tough. You have so much to offer other even when you are not feeling your best. Thank you so much for being your genuine selves! Hugs, Anita
  • #mcknighm77
    THANK YOU
    I love this podcast. I enjoy all of the episodes especially the one with with Chad King
  • Lisard01
    Thank you Chad King!
    Thank you for sharing your story with us! Thank you for sharing your creativity & music with us! You are a beacon of light in the darkness!
  • Earlyriser22
    Heartfelt and raw
    I was diagnosed five years ago and these ladies candid conversations, laughters and tears keep me going and make me realize I am not alive. Thank you for putting voices to this painful disease and am grateful for the inspiration you bring. Thank you and sending love
  • MrsMustard
    Chad King
    What an amazing sweet soul. I have never heard of him but you bet I will look him up. I need to know what song he did that touched Christina so much. Hugs sweet man. You are amazing!
  • Gena 427
    One Day At A Time
    Hello, I was diagnosed with RMS December 17, 2017. It has been quite the journey and I attack life one day at a time. My daily to do list is my saving grace. From reminders about meds, drinking water and using the bathroom, LOL, my bladder needs reminders too. Thank you for presenting your real selves every week for me and our fellow MS Warriors 🥰
  • * =)*
    Thankful
    As a 27 year old navigating a new MS diagnosis, this podcast is such a safe place for me.
  • Busbaby
    First-time listener
    I love this pod even more than I knew I would. Great chemistry between the hosts, intelligent and interesting interview too!
  • This is a tough one
    Heartbroken
    I have not yet been diagnosed but all signs are leading up to this. I’m waiting on my MRI and to be scheduled with a neurologist. I’m terrified, I’m heartbroken I don’t want this for my life. I’m mom so I take care of everyone.it breaks my heart to think one day I may not be able to. However I am lucky that my kids are grown. As silly as it sounds I think to myself this may rob me of baking and doing decorative cookies. I know so silly right but baking has helped me come out of some nasty times where I have as so depressed. I’ve had symptoms for a really long time finally I had a bad episode and broke down and told the Nurse practitioner I see and work with. I’m so blessed she’s hearing me out and not ignoring me. I’m not sure how I even heard about this podcast but I have really enjoyed listening to you guys. I don’t know anyone around me who has MS and I feel so alone. Listening to you guys I feel like we’re sitting in the same room chatting like girlfriends do. Anyway enough rambling. Lol Love always Amanda ♥️❤️
  • NatD_55
    Thank you!
    I was diagnosed in July 2024 and just found this podcast. I feel “seen” for the first time since July and am so thankful for you both. Thank you for being vulnerable and honest and saying the quiet parts out loud!! So nice not to feel alone.
  • BarbraJoMoHo
    John King
    Wow… felt like he was speaking for me. He was explaining everything I could not put into words. Thank you John
  • leala980
    LOVE this podcast!!
    My #1 podcast. I’ve been obsessed with Christina my whole life. I grew up to her on TV. Found & loved Jamie-Lynn on Sopranos. I love what y’all are doing & the community you’re building.
  • LjDeG
    Concerns
    Is Christina safe through these fires?
  • N. Lawson
    Helping Me Cope
    I was diagnosed a few months ago. I’ve never been a podcast listener, but I heard about this one and now it’s the only one I listen to. I anticipate new episodes every week. It’s been helping me cope right now.
  • Jill Bitt
    How about shaking it up
    I look forward to this podcast, interview authors
  • agraves59
    Yes!!!
    I’m also a mom of three kids who has been battling MS since 2000. I appreciate your honesty, even when it’s not pretty, and the empowerment you give to all in the MS community. Being a mom and having MS is not for the faint of heart but it’s also not impossible. We are capable of so much more than we give ourselves credit for.
  • MeSsy in CLE
    Thank you!
    Thanks, Jaime and Christina. Look so forward to MeSsy on Tuesday mornings. Love your honesty. Such a great podcast. Thanks for sharing your stories. I love to hear your perspective. I was diagnosed eight years ago at 51. My symptoms are fatigue, weakness on right leg from hip to ankle, changing gait. I’ve gone from looking cute in my heels to wearing tennis shoes almost everywhere and wondering if I’m the only one who can tell I’m walking “weird”. There have been a few positives since the diagnosis but mostly it’s just a worry about what’s to come.
  • Karebee
    Silver Lining of Gratitude
    I needed this show so much when I found it! I am one of those annoying people you refer to that is living almost normally with MS. However, this disease reeks invisible havoc on my body and wellbeing. I can’t run anymore but I can walk. Living in this capitalist world that punishes weakness and the need to rest is a constant struggle, one that has brought me to a breaking point more than a few times. I really love what these women have to say and relate to their struggles but have also made me so grateful that I can still do so many things. I am going to do the things I love while I still can. Thanks for helping me find this perspective of gratitude.
  • Trudy112233
    Bravo!
    Excellent podcast, heartfelt and much-needed. Thank you.
  • JenReyks
    Episode 25
    This episode was everything I feel!! Thank you!
  • stevenston
    Best podcast ever!
    I was sitting at my infusion center scrolling through my podcasts while I was getting one of my 6 month infusions, and I came across this wonderful podcast. I can’t begin to say how happy I am to hear these two amazing women talk about their MS issues because it helps me to know I’m not the only one struggling. It also helps that they are both so real while talking about these problems. They truly take the words out of my mouth when I’m talking about MS and the struggles that come with it.
  • JennyRColorado
    Every episode with the perfect card!
    Crying as always listening to the latest episode. So grateful to listen to these beautiful conversations between two amazing women.
  • The Browns of NH
    Gained a Fan Today
    Yup, looks like I’ll be catching up on 36 or so episodes. I started on episode 37 and Christina blew my mind twice. First with the DNA transfer to the brains I had never heard of and reading about the brain is a hobby here. Incredible piece of information! Then she stuns me with the 5 movies. I just figured out my tortured self in 5 minutes! I’ve been a spiritual counselor for decades and also suffer from autoimmune disease and rare stroke recovery in my 40’s. Some honest good women who don’t mind dishing out some raw emotion attached to real experiences. We do need this…we don’t need to hide it like we’re told.
  • Sueschlind
    Helps with MS
    My husband and I listen together. I’ve had ms over 40 years, and still struggle physically and emotionally with it. However, I’m disappointed with Christina’s view of women who voted differently than her, because I am one of them. I will still listen occasionally.
  • Julescode
    Refreshing and Real!
    Having been on a show with Marty I reveled in the unique qualities of his personality and showmanship. I grew up on Kelly Bundy, and later in my years devoured the Meadow years, so to hear real-life perspectives from you all with the spilt milk of Hollywood humor and real world challenges reminds us all, I must say, that we all suffer the imperfect human condition and this podcast is both real and refreshing.
  • 3bpml
    Unfollowed for Christina
    Wow! Used to be a big fan but since Christina hates me because of my vote I will unfollow. You celebrities might need to start realizing no one cares what you think, you are overpaid for doing nothing important.
  • Written Art
    Balance
    The conversation is interesting, not crazy about the language but it is like listening in on two girlfriends talking about things few of us have anyone to be so open with in our lives. So that is indeed, refreshing. Less refreshing? The over the top number of commercials. But at least they do them which is good & bad. Sometimes I can’t tell if I lm listening to their conversation or listening to another ad presented as conversation.
  • Lizzie Fernandes 23
    Curious❓❓
    Is HoneyLove still a sponser❓❓❓
  • Kellie Baldwin
    Nail on the head
    I feel so validated listening to this podcast, I just want to scream! I’ve been living with MS for six years and it’s so helpful being able to hear these honest conversations about all the experiences that come with this condition. Thank you for opening up and sharing your stories! It’s a true source of strength!
  • TinkBedell
    Grateful for the MeSsy podcast
    Dear Cristina and Jamie-Lynn, Thank you both for creating the MeSsy podcast, I am such a fan! I don’t personally know anyone else who has MS and find it helpful to hear you share your own experiences with MS. I find them so relatable and validating. I was officially diagnosed with secondary progressive MS in 2018, when I was 58 years old. I had several MS episodes beginning in my 30s. Often, by the time I went to a doctor regarding the odd symptoms I had been experiencing, the symptom would disappear. A few of the physicians I had, told me that my symptoms “might be MS” but they also said it’s not easy to diagnose and they didn’t want to record it in my medical record because it would likely make it difficult for me to get health insurance later, due to having a “previously existing condition” and the exclusions surrounding that. (Thank you President Obama for ending that issue). These days, I have a wonderful neurologist and team of physicians, who listen and are helpful during especially difficult issues with my MS. When I was finally diagnosed, I felt both relief and grief. I was relieved to finally know what was wrong with me, causing the many symptoms I had been experiencing. And grief for the many activities I can no longer participate in. While listening to your podcast, I often find myself laughing out loud hearing Christina’s stories and her proclivity to throw an F-bomb here and there. And Jamie-Lynn, your empathy, compassion and caring words toward Christina and your guests on the podcast are inspiring and helpful to hear. Your story about Beau, brought me to tears …I feel relieved to know that he is doing better. Others are not so accepting of my disease. I no longer have a relationship with my brother because he doesn’t deal well with sick people and considers my MS symptoms as “excuses” for not doing things he thinks I should be doing. It’s hurtful to hear him talk about my inconvenient disease but I’m trying to accept it. Do either of you have any thoughts on dealing with something like this? I am grateful to have found your podcast and look forward to listening every Tuesday morning, please keep sharing. My kindest thoughts and energy go out to you both. And so it is, Karen
  • Peggy3377
    Thank you!
    I haven't missed one of your podcasts and look forward to a new one every week. It's like talking on the phone to a couple of good friends (only they have MS and are so open and honest about everything!) Thank you for everything you do! I'm going on 22 years. I have learned so much from you....which has lead me to be more honest with friends and family) I love both of you and your sense of humor. I want to hang out with you and talk....love your friendship! Thanks again for your podcast and know you have lots and lots of people that listen! Marguerite Burtrum
  • Lenny is my Sunshine
    Trump Voter
    I’m a woman who voted for Trump. I used to love this podcast, but not after Christina insulted Trump voters. Sadie sounds uneducated about Trump’s policies, just like her mother. Instead of watching Bravo shows and pissing in her diapers, maybe Christina should take the time to learn about a leader who supports having secure borders, promoting the U.S. economy, and bringing stability to our country? Or, at the bare minimum, maybe Christina can learn that Americans do not care about the political views of entitled celebrities?
  • lakitty712
    Messy is beautiful!
    Thank you to our hosts for bringing honesty and comedy and truth to us every week. If I were a major network or streaming service, I would be pitching you daily. We want you -just as you -are to expand your reach and change the world. The more “messy” the better! Thank you for this gift. ❤️
  • SkO Girl
    One Mom Grieves, All Moms Grieve
    I am listening to the episode with Jessica Klepser. I can hear you guys crying and I’m Crying with you. I lost my son 2 years ago. My heart aches every day but I have also found my way out of going down a black hole for the rest of my life. I started writing him letters every day, I started a podcast, and writing a book. I interviewed a man Colin Campbell, who you might have heard of. He wrote “Finding The Words” which is all about exactly what you guys are talking about. He lost his 2 children in 2 horrific crash. Like him, you are touching my heart & my soul. Thanks so much for sharing. Sending love to you all. Great podcast! Blue skies…
  • Amy G (NYC)
    Thanks for bringing this to the light
    So grateful this podcast was brouggt to my brought to my attention by my bff. Im legally blind with extreme low vision and a congenital condition called EEC Syndrome which is Googleable. Most of the topics, issues feelings coping skills covered in these podcastels are translatable wnd its a beautiful feeling im not alone. Thanks ladies for the great work and keep it going. Much lov light and peace
  • RebeccaMG13
    Love your podcast
    I have mental illness and I relate to a lot of issues around acceptance etc. I am sending prayers and for both of your families!!! I hope Beau continues to improve!!!!!!!❤️❤️❤️❤️❤️❤️❤️❤️
  • SamStarr82
    You guys.
    I just started listening today and am through like 3 episodes already. I was diagnosed 10 yrs ago, have a 2.5 year old and think AIRPORTS ARE THE WORST and I’m always the caboose and and AND. You guys have given voice to all of the conversations I’ve had (mostly) in my head about my abilities, my fears, my anxieties. Everything. Thank you. thank you. Thank you. I love you both, from one ‘falling into walls’ mom to two others. Thank you. ❤️🫶🏽I can’t wait to listen to it all. Side note: can we start a chat group/page about things that actually DO help out?! Like grocery pick ups (thx covid!) to yoga nidra (I swear this literally has given my unable to sleep brain actual rest?!) that kind of thing. Anyway. Much love.
  • Clareberry4
    The club
    Being part of this club has its ups and downs, but I am proud to be a member with the likes of you two. Thank you for speaking up for all of us.
  • gotanna
    Lip smacking
    I would like to listen to them but there’s way too much lip smacking. Can’t listen to that.
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